Lymphatic filariasis and Brugia timori: prospects for elimination.
Identifieur interne : 008774 ( Main/Exploration ); précédent : 008773; suivant : 008775Lymphatic filariasis and Brugia timori: prospects for elimination.
Auteurs : Peter Fischer [Allemagne] ; Taniawati Supali ; Rick M. MaizelsSource :
- Trends in parasitology [ 1471-4922 ] ; 2004.
Descripteurs français
- KwdFr :
- Albendazole (usage thérapeutique), Animaux, Brugia (croissance et développement), Brugia (immunologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (usage thérapeutique), Filariose lymphatique (), Filariose lymphatique (diagnostic), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Indonésie (épidémiologie), Mâle, Population rurale, Prévalence.
- MESH :
- croissance et développement : Brugia.
- diagnostic : Filariose lymphatique.
- immunologie : Brugia.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Filaricides.
- épidémiologie : Filariose lymphatique, Indonésie.
- Animaux, Femelle, Filariose lymphatique, Humains, Mâle, Population rurale, Prévalence.
- Wicri :
- geographic : Indonésie.
English descriptors
- KwdEn :
- Albendazole (therapeutic use), Animals, Brugia (growth & development), Brugia (immunology), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (diagnosis), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (prevention & control), Female, Filaricides (therapeutic use), Humans, Indonesia (epidemiology), Male, Prevalence, Rural Population.
- MESH :
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Filaricides.
- geographic , epidemiology : Indonesia.
- diagnosis : Elephantiasis, Filarial.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial.
- growth & development : Brugia.
- immunology : Brugia.
- prevention & control : Elephantiasis, Filarial.
- Animals, Female, Humans, Male, Prevalence, Rural Population.
Abstract
Brugia timori is a pathogenic filarial nematode of humans, replacing the closely related species Brugia malayi on some islands in eastern Indonesia. Recent studies on Alor island show that, locally, B. timori is still of great public health importance, causing mainly acute filarial fever and chronic lymphedema. PCR-based assays to detect parasite DNA, in addition to assays for detecting specific antibodies that have been originally developed for B. malayi, can be used efficiently as diagnostic tools for B. timori. In the framework of the Global Program to Eliminate Lymphatic Filariasis, a single annual dose of diethylcarbamazine, in combination with albendazole, was found to reduce the prevalence and density of microfilaraemia persistently. Therefore, elimination of B. timori appears to be achievable.
DOI: 10.1016/j.pt.2004.06.001
PubMed: 15246315
Affiliations:
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Pfischer@bni-hamburg.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Strasse 74, D-20359 Hamburg</wicri:regionArea><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>20359 Hamburg</wicri:noRegion><wicri:noRegion>D-20359 Hamburg</wicri:noRegion></affiliation></author><author><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></author><author><name sortKey="Maizels, Rick M" sort="Maizels, Rick M" uniqKey="Maizels R" first="Rick M" last="Maizels">Rick M. 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Recent studies on Alor island show that, locally, B. timori is still of great public health importance, causing mainly acute filarial fever and chronic lymphedema. PCR-based assays to detect parasite DNA, in addition to assays for detecting specific antibodies that have been originally developed for B. malayi, can be used efficiently as diagnostic tools for B. timori. In the framework of the Global Program to Eliminate Lymphatic Filariasis, a single annual dose of diethylcarbamazine, in combination with albendazole, was found to reduce the prevalence and density of microfilaraemia persistently. Therefore, elimination of B. timori appears to be achievable.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Maizels, Rick M" sort="Maizels, Rick M" uniqKey="Maizels R" first="Rick M" last="Maizels">Rick M. Maizels</name><name sortKey="Supali, Taniawati" sort="Supali, Taniawati" uniqKey="Supali T" first="Taniawati" last="Supali">Taniawati Supali</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Fischer, Peter" sort="Fischer, Peter" uniqKey="Fischer P" first="Peter" last="Fischer">Peter Fischer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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